Zepbound Cost Calculator
Zepbound (tirzepatide) has a US list price of $1,086 per month, about $13,032 per year. Self-pay through LillyDirect runs $299 to $449 per month by dose. Pick how you pay below to estimate your real cost.
$299 to $449/month by dose via LillyDirect, if you refill within 45 days.
Protect your $5,388 investment
of rapid weight loss can be muscle, not fat, when protein intake is low: a slower metabolism and easier regain.
Get your daily protein number with the free GLP-1 protein calculator, then hit it every day with Protein Pal.
Pricing disclaimer: Figures are estimates from manufacturer published pricing as of September 2026 and change frequently. Eligibility rules apply to savings offers and self-pay programs; government program beneficiaries are typically excluded. This page is not medical or financial advice. Confirm current pricing with LillyDirect, your pharmacy or your insurer.
How Much Does Zepbound Cost in the US?
Zepbound's list price is $1,086 per month, about $13,032 per year as of September 2026. Most people pay far less:
- LillyDirect self-pay: Eli Lilly sells Zepbound single-dose vials direct for $299 to $449 per month depending on dose, if you refill within 45 days of the previous order. Miss the window and higher prices apply.
- Commercial insurance plus savings card: copays can drop as low as $25 per month for eligible patients, though weight management coverage varies a lot by plan.
- Medicare and Medicaid: government program beneficiaries are excluded from the self-pay and savings card offers.
At the LillyDirect prices, a year on Zepbound costs about $3,588 to $5,388. The same tirzepatide molecule is sold as Mounjaro for type 2 diabetes, which has no self-pay program.
Protect What Zepbound Costs You
Zepbound produces some of the fastest weight loss of any GLP-1 medication, which makes muscle protection matter more, not less. Without enough protein and resistance exercise, roughly a quarter of rapid weight loss can be lean mass. Hit a daily protein floor of 0.54g per lb (1.2g/kg): get your number with the Zepbound protein calculator, and read how much protein you need on Zepbound.
Pricing source: LillyDirect's Zepbound page, checked September 2026. Prices change often; confirm with the source before making decisions.